Research & Development

Our team

We have a team of highly qualified & experienced scientist / chemists with very well experienced consultants are available.

Dr. Atish Rodge
Founder and Managing Director
Education

Post Doc: Seoul National University, Seoul South Korea

Ph. D – SRTM (Swami Ramanand Tirth University) Nanded, Maharashtra, INDIA
Post Graduation: Shri Shivaji Science College Amravati, Maharashtra, INDIA
Graduation: Jagadamba College, Achalpur, Amravati, Maharashtra, INDIA

Research Contribution
PUBLICATIONS

  • The novel 3, 4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: Synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation. Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 15, 1 August 2011, Pages 4648-4651.
  • A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation. Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 10, 15 May 2012, Pages 3445-3448.
  • Novel derivatives of ISO-1 as potent inhibitors of MIF biological function. Bioorganic & Medicinal Chemistry Letters, Volume 19, Issue 16, 15 August 2009, Pages 4773-4776.
  • A fluorinated analogs of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis. European Journal of Pharmacology, Volume 607, Issues 1–3, 1 April 2009, Pages 201-212.
  • Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors. Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 19, 1 October 2011, Pages 5812-5817.
  • Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 24, 15 December 2008, Pages 6357-6361.
  • Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent, Bioorganic & Medicinal Chemistry Letters,Volume 22, Issue 20, 15 October 2012, Pages 6385-6390.
  • A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation, Bioorganic & Medicinal Chemistry Letters,Volume 22, Issue 10, 15 May 2012, Pages 3445-3448.
  • Synthesis, anti-inflammatory and antimicrobial evaluation of novel N1-(quinolin-4yl) ethane-1,2-diamine phenyl urea derivatives. Med Chem Res DOI 10.1007/s00044-012-0144-5.
  • The synthesis, anti-inflammatory and antimicrobial activity evaluation of novel thioanalogs of 3,4-dihydrothiopyrimidin-2(1H)-one derivatives of N-aryl urea. Med Chem Res DOI 10.1007/s00044-011-9943-3.
  • The synthesis, anti-inflammatory and anti-microbial activity evaluation of new series of 4-(3-arylureido)phenyl-1,4-dihydropyridine urea derivatives. Med Chem Res DOI 10.1007/s00044-012-0109-8.
  • Synthesis and anti-bacterial, anti-fungal activity of some novel chalcones derivatives. Chem. Pharm. Res., 2010, 2(5):348-355.
  • Synthesis and anti-bacterial, anti-fungal activity of novel 1, 2, 4-oxadiazole. Chem. Pharm. Res., 2011, 3(2):496-505.
  • Synthesis and biological evaluation of a novel series of methoxylated chalcones as antioxidant and anti-microbial agents. Chem. Pharm. Res., 2011, 3(6):639-648.

Patents

  • BICYCLIC GPR119 MODULATORS WIPO Patent Application WO/2012/069917.
  • OXI-INDOLE DEREVATIVES AS ANTI-INFLAMMATORY AGENTS Patent Application Yet be filed.

POSTER PRESENTATIONS

  • “Synthesis of Novel Chalcones Derivatives” In International conferences on “Drug Discovery and Nana-technology” at Nanded, Maharashtra, INDIA.
  • “Ionic liquid used in synthesis of Ibuprofen” In National Conference on “Green Chemistry and its Perspective” Department of Chemistry, Sant Gadge Baba Amravati University, Amravati – 444602 (MS), INDIA.
  • “Nanotechnology: Application of Heterogeneous Catalyst” In National Conference on “Green Chemistry and its Perspective” Department of Chemistry, Sant Gadge Baba Amravati University, Amravati – 444602 (MS), INDIA.
  • Attended 10th National Symposium in Chemistry on “Green Chemistry” (Feb 2008), Indian institute of science, Bangalore (Karnataka-India).
  • Participated in the 6th International Symposium on “Catalysis in Multiphase Reactor (CAMURE) and 5th International Symposium on Catalysis in Multifunctional Reactor (ISMR)” organized by the National Chemical Laboratory (INDIA) in January 2007

NATIONAL AND INTERNATIONAL CONTRIBUTION
Worked as Reviewer in following international journal.

  • Bio-organic Medicinal Chemistry.
  • Bio-organic Medicinal Chemistry Letter.
  • European Journal of Medicinal Chemistry.
  • Medicinal Chemistry Research.

Green Chemistry Letter and Reviewer
Research Experiences:

  1.  National Chemical Laboratory Pune
  2. Nicolas Primal Mumbai
  3.  Lupin research park Pune.
  4. and Pharmaceuticals Pvt. Ltd., Mumbai
  5. Work experiences in association:

Dr. Ram Vishwakarma (Director CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180 001)
Dr. Sarala Balachandran Project Director, OSDD Unit Council of Scientific and Industrial Research, Anusandhan Bhawan, Rafi Marg, New Delhi-110001
Dr. Sandip Bharate (Senior Scientist, Medicinal Chemistry Division, Assistant Professor (Chemical Sciences), AcSIR, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001,
Dr, S. S. Joshi (Scientist E, Process Development Department, National Chemical Laboratory, Pune).
Scientific meeting with Dr. Goverdhan Mehta, National Research Professor School of Chemistry, University of Hyderabad, Hyderabad 500 046, INDIA, Dr. R. A. Mashelkar presently the Director General of the Council of Scientific and Industrial Research.
Currently Dr. Atish is leading ‘Olympus Group’ as Managing Director.

Dr. Girish D. Hatnapure

Director (R&D)
Olympus Chemicals and Fertilizers

Education
PhD (Org. Chem.)/ M. Phil (Chemistry)
Dr. Girish is currently Director of Research and Development at Olympus Chemicals and Fertilizers. Prior to joining Olympus, Dr. Girish (Research associate) played over 7 yr active roles in Novel Drug Discovery and Development (NDDD) research efforts at Lupin (Pune, India). He has also worked as project assistant at National Chemical Laboratory, Pune. Dr. Girish has two patents and more than 15 publications to his credit. He received Ph.D. in Organic Chemistry from S.R.T.M. University Nanded (MH/India).
Outline of Experience
Over 8 year’s rich experience in R&D, synthetic medicinal chemistry and impurity profile in the leading research institute and pharmaceutical industry from India. During worked on different on therapeutic target rich experiences in various organic reaction, handle the multiple synthetic reagents and purification technique. Archive specialty in multistep synthesis and characterization of all synthetic compound using Mass (LCMS), NMR (Proton and 2D) HPLC. Active participation in the design of novel drug molecule (New chemical entities) as well as their synthetic strategies. Also have experiences in synthetic process development of lead molecule.
Current Responsibility – Design and development of R & D project, Review of analytical data and Quality control.
Research Contribution
Publications-

  • Synthesis and biological evaluation of novel piperazine derivatives of flavones as potent anti-inflammatory and antimicrobial agent.

Bioorganic & Medicinal Chemistry Letters, 22, 2012, 6385–6390.

  • Synthesis and biological evaluation of a novel series of methoxylated chalcones as antioxidant and anti-microbial agents.
  1. Chem. Pharm. Res., 3, 2011, 639-648.
  • Synthesis and anti-bacterial, anti-fungal activity of some novel chalcone derivatives.
  1. Chem. Pharm. Res., 2, 2010, 348-355.
  • Synthesis and biological evaluation of a novel 2′, 4′, 5′-trimethoxy flavonol derivatives as anti-inflammatory and antimicrobial agents.

Medicinal Chemistry Research, DOI 10.1007/s00044-013-0651-z

  • Synthesis, anti-inflammatory and antimicrobial evaluation of novel N1-(quinolin-4yl) ethane-1, 2-diamine phenyl urea derivatives.

Medicinal Chemistry Research, 22, 2013, 1480-1487

  • The synthesis, anti-inflammatory and anti-microbial activity evaluation of new series of 4-(3-arylureido) phenyl-1, 4-dihydropyridine urea derivatives.

Medicinal Chemistry Research, 22, 2013, 1450-1455

  • Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties.

Bioorganic & Medicinal Chemistry Letters, 22, 2012, 6611–6615.

  • A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation.

Bioorganic & Medicinal Chemistry Letters, 22, 2012, 3445–3448.

  • The synthesis, anti-inflammatory and antimicrobial activity evaluation of novel thioanalogs of 3, 4-dihydrothiopyrimidin-2(1H)-one derivatives of N-aryl urea.

Medicinal Chemistry Research, 21, 2012, 4252-4260.

  • Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent.

Bioorganic & Medicinal Chemistry Letters, 22, 2012, 6385-6390.

  • The novel 3, 4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: Synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation.

Bioorganic & Medicinal Chemistry Letters, 21, 2011, 4648-4651.

  • Synthesis and anti-bacterial, anti-fungal activity, of novel 1, 2, 4-oxadiazole.
  1. Chem. Pharm. Res., 3, 2011, 496-505.

Posters-

  • Poster presentation on “Synthesis of novel Chalcone derivative”

Girish Hatnapure*, Atish Rodge, Ashish Keche, Ravindra Jumde; International   conferences on Drug discovery and Nano-technology (26-27 Jan-2008), Nanded, Maharashtra India.

  • Poster presentation on “Nanotechnology: Application of Heterogeneous Catalyst” H. Rodge, G. D. Hatnapure, R. P. Jumde, A. P. Keche, M. W. Bhade, S. T. Bhoge, .  Dr.P.R. Padole, M.J. Pawar.* In “National Conference on Green Chemistry and its Perspective”. (11-12 Feb-2008), Department of Chemistry, Sant Gadge Baba Amravati University, Amravati –India.

 

Dr Ashish P. Keche

Director (R&D) Olympus Chemicals and Fertilizers

Education

PhD (Org. Chem.)/ M. Phil (Chemistry)
Dr. Girish is currently Director of Research and Development at Olympus Chemicals and Fertilizers. Prior to joining Olympus, Dr. Girish (Research associate) played over 7 yr active roles in Novel Drug Discovery and Development (NDDD) research efforts at Lupin (Pune, India). Also worked as project assistant at National Chemical Laboratory, Pune. Dr. Girish has two patents and more than 15 publications to his credit. He received Ph.D. in Organic Chemistry from S.R.T.M. University Nanded (MH/India).
Research Experiences
Dr. Ashish have over 8+year of research experience in pharmaceutical industry and as well as good academic achievements. He worked with well-known Indian scientists like Dr, R. M. Deshpande (Scientist E, Process Development Department, National Chemical Laboratory, Pune), Dr. Ram Vishwakarma (Director CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180 001), Dr. Sham Nikam (Vice President, Head Global Discovery and Chief Scientific Officer, India, Takeda Pharmaceuticals International GmbH), Dr. Pratap Reddy (Senior Vice President, Macleod’s Parma, Andheri, Mumbai, INDIA).
Mainly his experience involves the development of various API’s and its impurities also consist of different types of chemistry like coupling reactions, substitution reactions, addition reactions, elimination reactions, redox reactions, functional group inter conversions, protection & deprotection chemistry, also expertise in different purification techniques such as column chromatography, recrystallization, precipitation, etc.  He has strong practical hand for the cost effective synthesis of impurities and route of selection.
Current Responsibility – Design and development of R & D project with cost effective synthesis, R & D work Management and Dispatch of projects.
Research Contribution

Publications-

  • Synthesis and biological evaluation of novel piperazine derivatives of flavones as potent anti-inflammatory and antimicrobial agent.

Bioorganic & Medicinal Chemistry Letters, 22, 2012, 6385–6390.

  • Synthesis and biological evaluation of a novel series of methoxylated chalcones as antioxidant and anti-microbial agents.
  1. Chem. Pharm. Res., 3, 2011, 639-648.
  • Synthesis and anti-bacterial, anti-fungal activity of some novel chalcone derivatives.
  1. Chem. Pharm. Res., 2, 2010, 348-355.
  • Synthesis and biological evaluation of a novel 2′, 4′, 5′-trimethoxy flavonol derivatives as anti-inflammatory and antimicrobial agents.

Medicinal Chemistry Research, DOI 10.1007/s00044-013-0651-z

  • Synthesis, anti-inflammatory and antimicrobial evaluation of novel N1-(quinolin-4yl) ethane-1, 2-diamine phenyl urea derivatives.

Medicinal Chemistry Research, 22, 2013, 1480-1487

  • The synthesis, anti-inflammatory and anti-microbial activity evaluation of new series of 4-(3-arylureido) phenyl-1, 4-dihydropyridine urea derivatives.

Medicinal Chemistry Research, 22, 2013, 1450-1455

  • Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties.

Bioorganic & Medicinal Chemistry Letters, 22, 2012, 6611–6615.

  • A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation.

Bioorganic & Medicinal Chemistry Letters, 22, 2012, 3445–3448.

  • The synthesis, anti-inflammatory and antimicrobial activity evaluation of novel thioanalogs of 3, 4-dihydrothiopyrimidin-2(1H)-one derivatives of N-aryl urea.

Medicinal Chemistry Research, 21, 2012, 4252-4260.

  • Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent.

Bioorganic & Medicinal Chemistry Letters, 22, 2012, 6385-6390.

  • The novel 3, 4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: Synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation.

Bioorganic & Medicinal Chemistry Letters, 21, 2011, 4648-4651.

  • Synthesis and anti-bacterial, anti-fungal activity, of novel 1, 2, 4-oxadiazole.
  1. Chem. Pharm. Res., 3, 2011, 496-505.

Posters-

  • Poster presentation on “Synthesis of novel Chalcone derivative”

           Girish Hatnapure*, Atish Rodge, Ashish Keche, Ravindra Jumde. International   conferences on Drug discovery and Nano-technology, (26-27 Jan-2008), Nanded, Maharashtra India.

  • Poster presentation on “Nanotechnology: Application of Heterogeneous Catalyst” H. Rodge, G. D. Hatnapure, R. P. Jumde, A. P. Keche, M. W. Bhade, S. T. Bhoge, .  Dr.P.R. Padole, M.J. Pawar.* In “National Conference on Green Chemistry and its Perspective”. (11-12 Feb-2008), Department of Chemistry, Sant Gadge Baba Amravati University, Amravati –India.

o.

Dr Gopal K. Toradmal

Research Scientist (R&D)
Olympus Chemicals and Fertilizers

Education
Ph.D :- Organic Chemistry, S. R. T. M University, Nanded.
M.Sc:- 2008 (7.31 CGPA), Industrial Chemistry, S. R. T M. University, Nanded.
B.Sc.- 2006 (60.16%) Chem, Bot and Micro, (D.S.M College Parbhani) S.R.T. M. University,
Nanded

Research Experiences
Ph. D. topic is “Development of an efficient and green protocols for C-C and CHeteroatom bond formation employing organoboron reagents,” and worked under the guidance of Dr. Rajesh H. Tale, Asst. Prof. During this work we have developed new methodologies for C-halogen bond formation which includes protocols for green ipso-iodination and NIMI (N-iodomorpholinium salt) assisted Cu-Catalysed ipso-iodination of arylboronic acids . The high quality work undertaken and successfully completed is evident by publishing the work in journals of international repute such as Tetrahedron Lett., RSC Advances etc. and 1,2,3-triazole ligand accelerated C-nitrogen coupling (Chan-Lam coupling) of isatin and C-boron coupling (Miyayura borylation ) of aryl bromides.Also we have developed novel ligand for Click chemistry Catalysis and many new ligands with excellent efficiency.

Current Responsibility

Synthesis, isolation and characterization impurities, literature search for project development and cost effective synthesis.

Research Contribution
1) Metal free ipso iodination of arylboronic acids using CTAB/I2 in aqueous media: Green and regioselective synthesis of aryliodides under mild condition. Rajesh H. Tale*, Gopal K. Toradmal, et al. Tetrahedron Lett. 2015, 56, 2699–2703.

  • A practical and general ipso iodination of arylboronic acids using N-iodomorpholinium iodide (NIMI) as a novel iodinating agent: mild and regioselective synthesis of aryliodides. Rajesh H.Tale*, Gopal K. Toradmal, Venkatesh B. Gopula. RSC Adv., 2015, 5, 84910.
  • Click ligand for click chemistry: (1-(4-methoxybenzyl)-1-H-1,2,3-triazol-4-yl)methanol (MBHTM) accelerated copper-catalyzed [3+2] azide-alkyne cycloaddition (CuAAC) at low catalyst loading. Rajesh H. Tale*, Venkatesh B. Gopula, Gopal K. Toradmal, Tetrahedron Lett.s, 2015, 56, 5864-5869.

2) Content – facilities

Facilities are available for complex molecules synthesis and routine organic synthesis reaction with strong online in-house analytical support.

  • A – Organic synthesis- facilities for ll types of dry reaction, reaction at-78 or below temperature, hydrogenation reaction pressure reaction, microwave reaction, enzymatic reaction and other all types of basic organic synthesis.
  • B – Analytical – LC_MS for online reaction monitoring, Shimazoo analytical HPLC for Purity, RT, RRT and RF monitoring, Silica gel column chromatography for the isolation/purification of impurities, waters preparative HPLC for isolation of degraded impurities, low % impurities from API, unknown impurities and other purification.

3) Content- Finished Product

Finished products are characterized by HNMR, 13CNMR, Mass/LC-MS, IR, Melting Point, CHN analysis, Purity RT, RRT and RF by HPLC and if necessary product is supported by 2DHNMR spectra

Facilities At Olympus 

  1. Facilities are available for the synthesis of complex organic molecules and all types of organic chemistry reaction.
  2. Facilities are available for high pressure reaction, microwave reaction and hydrogenation reaction.
  3. Facilities are available for dry reaction with temperature range 00C to -780C or below.
  4. Facilities are available for the isolation and identification of unknown impurities.
  5. Facilities are available for enzymatic reaction and degradation of final API to isolate impurities
  6. Facilities are available for parallel reaction and all.

.

  1. Facilities are available for the isolation of organic compound by silica gel column chromatography or Morden flash chromatography technique by using combi flash, grace or Bio-tage technique.
  2. Shimadzu LC solution HPLC Analysis systems are available for RT/RRT and peak purity confirmation as per pharmacopeia method or in house method.

           Shimadzu LC solution preparative HPLC is available for the isolation and identification of unknown impurities.

Mass and HNMR analysis will done in collaboration with other FDA approved testing laboratories.

Storage Facilities are available from room temperature to 0 0C to -780C.

  1. Solid and liquid compound are packed in high quality specially design high recovery vial with proper sealing and safety.
  2. Sensitive products are packed in specially design vial under flow of nitrogen and ship in 0 to -780C as per requirement.

All require analytical data as per standard guideline will generate and ship with compound and soft copy by mail.